The search for a predictor of CD4 cell count continues: Total lymphocyte count is not a substitute for CD4 cell count in the management of HIV-Infected individuals in a resource-limited setting

被引：27
|
作者：
Akinola, NO [1 ]
Olasode, O
Adediran, IA
Onayemi, O
Murainah, A
Irinoye, O
Elujoba, AA
Durosinmi, MA
机构：
[1] Obafemi Awolowo Univ, Fac Basic Med Sci, Dept Haematol & Immunol, Ife, Nigeria
[2] Obafemi Awolowo Univ, Dept Dermatol & Venereol, Ife, Nigeria
[3] Obafemi Awolowo Univ, Dept Nursing Sci, Ife, Nigeria
[4] Obafemi Awolowo Univ, Dept Pharmacognosy, Ife, Nigeria
来源：
CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 04期
关键词：
D O I：
10.1086/422722
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of <200 cells/mm(3) were found in 42 cases (37.8%) with TLCs of ≥1200 cells/mm(3). Thus, 1 in 3 individuals would have been deprived of needed treatment. Therefore, in this setting, TLC is not a reliable predictor of CD4 cell count in HIV-infected individuals.
引用
收藏
页码：579 / 581
页数：3
相关论文
共 50 条
  • [1] Is total lymphocyte count a reliable predictor of the CD4 lymphocyte cell count in resource-limited settings?
    Liotta, G
    Perno, CF
    Ceffa, S
    Gialloreti, LE
    Coehlo, E
    Erba, F
    Guidotti, G
    Marazzi, MC
    Narciso, P
    Palombi, L
    AIDS, 2004, 18 (07) : 1082 - 1083
  • [2] Total lymphocyte CD4 cell count to count as a possible surrogate of prioritize eligibility for antiretroviral therapy among HIV-infected individuals in resource-limited settings
    Bedell, R
    Heath, KV
    Hogg, RS
    Wood, E
    Press, N
    Yip, B
    O'Shaughnessy, MVO
    Montaner, JSG
    ANTIVIRAL THERAPY, 2003, 8 (05) : 379 - 384
  • [3] Total lymphocyte count as a surrogate marker for CD4 count in resource-limited settings
    Christian Obirikorang
    Lawrence Quaye
    Isaac Acheampong
    BMC Infectious Diseases, 12
  • [4] Total lymphocyte count as a surrogate marker for CD4 count in resource-limited settings
    Obirikorang, Christian
    Quaye, Lawrence
    Acheampong, Isaac
    BMC INFECTIOUS DISEASES, 2012, 12
  • [5] Evaluating Total Lymphocyte Count as a Surrogate Marker for CD4 Cell Count in the Management of HIV-Infected Patients in Resource-Limited Settings: A Study from China
    Chen, Jieqing
    Li, Wei
    Huang, Xiaojie
    Guo, Caiping
    Zou, Ran
    Yang, Qiuying
    Zhang, Hongwei
    Zhang, Tong
    Chen, Hui
    Wu, Hao
    PLOS ONE, 2013, 8 (07):
  • [6] Correlation analysis on total lymphocyte count and CD4 count of HIV-infected patients
    Liu, F. R.
    Guo, F.
    Ye, J. J.
    Xiong, C. F.
    Zhou, P. L.
    Yin, J. G.
    Ye, L. X.
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2008, 62 (06) : 955 - 960
  • [7] Absolute lymphocyte count as a predictor of CD4 count
    Shapiro, NI
    Karras, DJ
    Leech, SH
    Heilpern, KL
    ANNALS OF EMERGENCY MEDICINE, 1998, 32 (03) : 323 - 328
  • [8] Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia
    Yitayih Wondimeneh
    Getachew Ferede
    Gizachew Yismaw
    Dagnachew Muluye
    AIDS Research and Therapy, 9
  • [9] Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia
    Wondimeneh, Yitayih
    Ferede, Getachew
    Yismaw, Gizachew
    Muluye, Dagnachew
    AIDS RESEARCH AND THERAPY, 2012, 9
  • [10] CD4 count and CD4% in African HIV-infected people
    Anglaret, X
    Sylla-Koko, F
    Diagbouga, S
    Combe, P
    Van de Perre, P
    Dabis, F
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1998, 27 (05) : 928 - 929
12345