Epigenomics: Beyond CpG islands

被引：247

作者：

Fazzari, MJ

Greally, JM

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Med Hematol & Mol Genet, Bronx, NY 10461 USA

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrg1349

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenomic studies aim to define the location and nature of the genomic sequences that are epigenetically modified. Much progress has been made towards whole-genome epigenetic profiling using molecular techniques, but the analysis of such large and complex data sets is far from trivial given the correlated nature of sequence and functional characteristics within the genome. We describe the statistical solutions that help to overcome the problems with data-set complexity, in anticipation of the imminent wealth of data that will be generated by new genome-wide epigenetic profiling and DNA sequence analysis techniques. So far, epigenomic studies have succeeded in identifying CpG islands, but recent evidence points towards a role for transposable elements in epigenetic regulation, causing the fields of study of epigenetics and transposable element biology to converge.

引用

页码：446 / 455

页数：10

共 104 条

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