Synthesis of a 1-benzylpiperazin-2-one nitrone and its reaction with alkynes and alkenes

被引：16

作者：

Bernotas, RC

Adams, G

机构：

[1] Hoechst Marion Roussel, Inc., Cincinnati, OH 45215

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 41期

关键词：

D O I：

10.1016/0040-4039(96)01640-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 1-benzylpiperazin-2-one nitrone has been synthesized. It readily undergoes [3+2] cycloadditions with alkynes and alkenes to give Delta(4)-isoxazolines and isoxazolidines, respectively, which can be reductively opened to 3-substituted piperazin-2-ones and 1,3-amino alcohols. Copyright (C) 1996 Elsevier Science Ltd

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页码：7339 / 7342

页数：4

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