Topical Anti-inflammatory Potential of Standardized Pomegranate Rind Extract and Ellagic Acid in Contact Dermatitis

被引：30

作者：

Mo, Jiao ^{[1
]}

Panichayupakaranant, Pharkphoom ^{[2
]}

Kaewnopparat, Nattha ^{[3
]}

Songkro, Sarunyoo ^{[3
]}

Reanmongkol, Wantana ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Clin Pharm, Hat Yai 90110, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90110, Songkhla, Thailand

[3] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Hat Yai 90110, Songkhla, Thailand

来源：

PHYTOTHERAPY RESEARCH | 2014年 / 28卷 / 04期

关键词：

Punica granatum; topical application; inflammation; contact dermatitis; ellagic acid; PUNICA-GRANATUM; INFLAMMATION; ANTIOXIDANT; JUICE; SUPPRESSION; INHIBITION; EDEMA; PEEL; SKIN; OIL;

D O I：

10.1002/ptr.5039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study evaluated the topical anti-inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol-induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose-dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：629 / 632

页数：4

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