CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer

被引：25
作者：
Zhang, Yunqiang [1 ,2 ]
Zang, Mingde [1 ]
Li, Jianfang [1 ]
Ji, Jun [1 ]
Zhang, Jianian [1 ]
Liu, Xiaolei [1 ]
Qu, Ying [1 ]
Su, Liping [1 ]
Li, Chen [1 ]
Yu, Yinyan [1 ]
Zhu, Zhenggang [1 ]
Liu, Bingya [1 ]
Yan, Min [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Inst Digest Surg, Shanghai Key Lab Gastr Neoplasms, Dept Surg,Ruijin Hosp,Sch Med, Shanghai 200025, Peoples R China
[2] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Shanghai 200040, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2014年 / 46卷 / 04期
基金：
中国国家自然科学基金;
关键词：
gastric cancer; CEACAM6; C-SRC; metastasis; invasion; CARCINOEMBRYONIC ANTIGEN FAMILY; CELL-ADHESION MOLECULES; PANCREATIC ADENOCARCINOMA; EXPRESSION; OVEREXPRESSION; PROTEINS; TISSUES; GENES; CEA;
D O I：
10.1093/abbs/gmu001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer (GC) cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator (C-SRC) phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.
引用
收藏
页码：283 / 290
页数：8
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