Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System

被引：22

作者：

Rodriguez, Ana M. ^{[1
]}

Victoria Delpino, M. ^{[1
]}

Cruz Miraglia, Maria ^{[2
]}

Giambartolomei, Guillermo H. ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Inst Inmunol Genet & Metab INIGEM, CONICET, Buenos Aires, DF, Argentina

[2] INTA, Ctr Invest Ciencias Vet & Agronom CICVyA, Inst Virol, Buenos Aires, DF, Argentina

来源：

NEUROSCIENCE | 2019年 / 410卷

关键词：

neurobrucellosis; neuroinflammation; glial activation; neurotoxicity; blood brain barrier; BRUCELLA-ABORTUS INFECTION; OUTER-MEMBRANE PROTEINS; HOST INNATE RESISTANCE; IV SECRETION SYSTEM; REACTIVE ASTROCYTES; CEREBROSPINAL-FLUID; CELL-DEATH; KEY ROLE; BRAIN; ACTIVATION;

D O I：

10.1016/j.neuroscience.2019.05.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：264 / 273

页数：10

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