Spherical Caps in Cell Polarization

被引：27

作者：

Diegmiller, Rocky ^{[1
,2
]}

Montanelli, Hadrien ^{[3
]}

Muratov, Cyrill B. ^{[4
]}

Shvartsman, Stanislav Y. ^{[1
,2
]}

机构：

[1] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[3] Columbia Univ, Dept Appl Phys & Appl Math, New York, NY USA

[4] New Jersey Inst Technol, Dept Math Sci, Newark, NJ 07102 USA

来源：

BIOPHYSICAL JOURNAL | 2018年 / 115卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

REACTION-DIFFUSION SYSTEMS; PAR PROTEINS; POLARITY; MODEL; YEAST; INSTABILITIES; BIFURCATION; SYMMETRY; PATTERNS;

D O I：

10.1016/j.bpj.2018.05.033

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

引用

页码：26 / 30

页数：5

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