Perylene Diimide Oligomer Nanoparticles with Ultrahigh Photothermal Conversion Efficiency for Cancer Theranostics

被引：27

作者：

Gong, Qiuyu ^{[1
]}

Xing, Jie ^{[2
,3
]}

Huang, Yinjuan ^{[1
]}

Wu, Aiguo ^{[2
,3
]}

Yu, Jing ^{[1
]}

Zhang, Qichun ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[2] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China

[3] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 03期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

perylene diimides; photothermal agent; photothermal conversion efficiency; self-assembly; phototheranostics; SEMICONDUCTING POLYMER; NANOSTRUCTURES; NANOMEDICINES; ASSEMBLIES; NANOSHEETS; MOLECULES; THERAPY; OXIDE; SIZE;

D O I：

10.1021/acsabm.9b01187

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Developing one agent that has reasonable stability and ultrahigh photothermal conversion efficiency (PTCE) for near-infrared (NIR) photothermal cancer treatment remains a great challenge, but is highly desirable. In this research, we developed a perylene diimide (PDI)-based oligomer (OPDI) through coupling monomeric PDI derivatives together. OPDI exhibited slightly red-shifted absorption at NIR region compared with monomeric PDI. More importantly, the self-assembled OPDI nanoparticles not only exhibited high stability and preferable biocompatibility, but also possessed an ultrahigh PTCE (up to 79.8%, higher than many other photothermal agents reported before). This OPDI photothermal agent has been demonstrated to exhibit excellent therapeutic effects. Our research provides a guide for the exploitation of photothermal agents with ultrahigh PTCE.

引用

页码：1607 / 1615

页数：9

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