Education Exerts Different Effects on Cognition in Individuals with Subjective Cognitive Decline and Cognitive Impairment: A Population-Based Study

被引:20
作者
Chen, Guanqun [1 ,2 ]
Zhao, Mingyan [1 ,3 ]
Yang, Kun [4 ]
Lin, Hua [1 ]
Han, Chunlei [5 ]
Wang, Xiaoni [1 ]
Han, Ying [1 ,2 ,6 ]
机构
[1] Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing, Peoples R China
[2] Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
[3] Tangshan Gongren Hosp, Dept Neurol, Tangshan, Peoples R China
[4] Capital Med Univ, Dept Evidence Based Med, Xuanwu Hosp, Beijing, Peoples R China
[5] Univ Turku, Turku PET Ctr, Turku, Finland
[6] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; cognitive reserve; dementia; education; mild cognitive impairment; subjective cognitive decline; ALZHEIMERS-DISEASE; RISK; RESERVE; DEMENTIA; PROGRESSION; PREVENTION; PREVALENCE; COMPLAINTS; FRAMEWORK; CRITERIA;
D O I
10.3233/JAD-201170
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Education plays a potential important effect on the prevalence and incidence of dementia. However, most of the evidence based on convenience sampling. Objective: To explore effects of education on cognition in individuals with subjective cognitive decline (SCD) and cognitive impairment (CI) from a population-based study. Methods: We examined the effect of education on cognition among individuals with SCD (n = 451) and CI (n = 280) from a population-based study. A series of neuropsychological tests of memory, executive, language, and general cognitive function were used to assess the participants. Results: Multiple regression analyses revealed that education has a positive effect on cognition in both SCD and CI group in the population-based research. Further stratification study showed that the beneficial effect of education remains in the SCD group regardless of the education level, especially in the SCD participants with a low education level. However, that effect of education exists in the CI group with a low education level and disappears in the high education level. Conclusion: These results from a population-based sample suggest that high educational attainment may delay cognitive decline in the individuals with SCD regardless of high or low educational level, and high education only predicts cognition in those in the low educational level in CI group.
引用
收藏
页码:653 / 661
页数:9
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