Chemoselective synthesis of hetero cyclic derivatives of 18-nor equilenine, 16-substituted-12H-11-oxa-15-aza-17-thia-cyclopenta[a] phenanthrenene and their in vitro evaluation of antibacterial and antifungal activity

被引：0

作者：

Malviya, N. J.

Kulkarni, A. M.

Jaimini, D.

Jadhav, B. L.

Karnik, A. V. ^{[1
]}

机构：

[1] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India

[2] Univ Bombay, Dept Life Sci, Bombay 400098, Maharashtra, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2006年 / 45卷 / 06期

关键词：

heterosteroids; chemoselectivity; azasteroids; thiasteroids; oxasteroids; antibacterial activity; antifungal activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemoselective synthesis of heterocyclic derivatives of 18-norequilenine, 16-substituted-12H-11-oxa-15-aza-17-thiacyclopenta[a]phenanthrene 4a-j is presented. These molecules 4a-j have exhibited moderate to good antibacterial activity against some grain-positive and grain-negative bacteria.

引用

页码：1499 / 1503

页数：5

共 24 条

[1]

AKHERM AA, 1979, CHEM ABSTR, V90, DOI UNSP 104211U

[2] BIOLOGICAL ACTIVITY IN STEROIDS POSSESSING NITROGEN ATOMS .2. STEROIDAL ALKALOIDS [J].