Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica

被引：40

作者：

Viegas, S. ^{[1
,2
]}

Weir, A. ^{[1
]}

Esiri, M. ^{[3
]}

Kuker, W. ^{[4
]}

Waters, P. ^{[2
]}

Leite, M. I. ^{[2
]}

Vincent, A. ^{[2
]}

Palace, J. ^{[1
]}

机构：

[1] John Radcliffe Hosp, Dept Clin Neurol, Oxford OX2 6HE, England

[2] John Radcliffe Hosp, Neurosci Grp, Weatherall Inst Mol Med, Oxford OX2 6HE, England

[3] John Radcliffe Hosp, Dept Clin Neuropathol, Oxford OX2 6HE, England

[4] John Radcliffe Hosp, Dept Clin Neuroradiol, Oxford OX2 6HE, England

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2009年 / 80卷 / 06期

关键词：

MULTIPLE-SCLEROSIS; MARKER;

D O I：

10.1136/jnnp.2008.157693

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study describes a young girl who presented with involuntary weight loss, spontaneous vomiting and behavioural change. Imaging confirmed hypothalamic and brainstem involvement. Routine investigations (including cerebrospinal fluid analysis and neuromyelitis optica IgG) were unhelpful. Biopsy of the hypothalamic lesion implicated an aggressive inflammatory aetiology. There was a response to conventional immunosuppression, while a further relapse responded to plasma exchange. She died 21 months after presentation. Postmortem examination was highly suggestive of neuromyelitis optica, which was subsequently confirmed following the identification of aquaporin 4 antibodies.

引用

页码：679 / 682

页数：4

共 17 条

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