Molecular mechanisms of tubulogenesis

被引：258
作者：
Hogan, BLM [1 ]
Kolodziej, PA
机构：
[1] Vanderbilt Univ, Med Ctr, Howard Hughes Med Inst, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Ctr, Dept Dev & Cell Biol, Nashville, TN 37232 USA
来源：
NATURE REVIEWS GENETICS | 2002年 / 3卷 / 07期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrg840
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behaviour, including cell polarization, tube migration to target sites, cell-fate diversification and localization of specialized cells to different regions of the tube system. Using examples from both invertebrate and vertebrate systems, this review highlights progress in understanding these basic principles and briefly discusses the possible evolution of strategies to regulate the morphogenesis of tubular systems.
引用
收藏
页码：513 / 523
页数：11
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