Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

被引:16
作者
Gamie, Zakareya [2 ]
MacFarlane, Robert J. [3 ,4 ]
Tomkinson, Alicia [5 ]
Moniakis, Alexandros [6 ]
Gui Tong Tran [7 ]
Gamie, Yehya [8 ]
Mantalaris, Athanasios [3 ]
Tsiridis, Eleftherios [1 ,9 ]
机构
[1] Aristotle Univ Thessaloniki, PapaGeorgiou Hosp, Sch Med, Acad Orthopaed Unit, GR-54634 Thessaloniki, Greece
[2] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn, London W12 0HS, England
[4] Royal Liverpool Univ Hosp, Dept Trauma & Orthopaed, Liverpool L7 8XP, Merseyside, England
[5] Huddersfield Royal Infirm, Dept Trauma & Orthopaed Surg, Huddersfield HD3 3EA, W Yorkshire, England
[6] Aristotle Univ Thessaloniki, Sch Med, GR-54634 Thessaloniki, Greece
[7] Univ Leeds, Sch Med, Acad Dept Trauma & Orthopaed, Leeds Gen Infirm, Leeds LS2 9JT, W Yorkshire, England
[8] Univ Sheffield, Sch Clin Dent, Acad Unit Restorat Dent, Sheffield S10 2TA, S Yorkshire, England
[9] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Div Surg, London W12 0HS, England
关键词
adipose; bone; cells; embryonic; engineering; marrow; scaffold; stem; tissue; umbilical; MARROW STROMAL CELLS; HUMAN BONE-MARROW; CALCIUM-PHOSPHATE CEMENT; BETA-TRICALCIUM PHOSPHATE; VIVO OSTEOGENIC DIFFERENTIATION; IN-VITRO PROLIFERATION; CRITICAL-SIZE DEFECTS; FIBER-MESH SCAFFOLDS; ADIPOSE-TISSUE; MORPHOGENETIC PROTEIN-2;
D O I
10.1517/14712598.2014.945414
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Introduction: Mesenchymal stem cells (MSCs) can be obtained from a wide variety of tissues for bone tissue engineering such as bone marrow, adipose, birth-associated, peripheral blood, periosteum, dental and muscle. MSCs from human fetal bone marrow and embryonic stem cells (ESCs) are also promising cell sources. Areas covered: In vitro, in vivo and clinical evidence was collected using MEDLINE (R) (1950 to January 2014), EMBASE (1980 to January 2014) and Google Scholar (1980 to January 2014) databases. Expert opinion: Enhanced results have been found when combining bone marrow-derived mesenchymal stem cells (BMMSCs) with recently developed scaffolds such as glass ceramics and starch-based polymeric scaffolds. Preclinical studies investigating adipose tissue-derived stem cells and umbilical cord tissue-derived stem cells suggest that they are likely to become promising alternatives. Stem cells derived from periosteum and dental tissues such as the periodontal ligament have an osteogenic potential similar to BMMSCs. Stem cells from human fetal bone marrow have demonstrated superior proliferation and osteogenic differentiation than perinatal and postnatal tissues. Despite ethical concerns and potential for teratoma formation, developments have also been made for the use of ESCs in terms of culture and ideal scaffold.
引用
收藏
页码:1611 / 1639
页数:29
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