Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction

被引:18
作者
Gatford, Kathryn L. [1 ,2 ]
Kaur, Gunveen [3 ]
Falcao-Tebas, Filippe [3 ]
Wadley, Glenn D. [4 ]
Wlodek, Mary E. [5 ]
Laker, Rhianna C. [5 ,6 ]
Ebeling, Peter R. [7 ]
McConell, Glenn K. [3 ,8 ]
机构
[1] Univ Adelaide, Robinson Inst, Adelaide, SA, Australia
[2] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia
[3] Victoria Univ, Coll Sport & Exercise Sci, ISEAL, Melbourne, Vic 8001, Australia
[4] Deakin Univ, Sch Exercise & Nutr Sci, Ctr Phys Act & Nutr Res, Burwood, Vic, Australia
[5] Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia
[6] Univ Virginia, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA USA
[7] Univ Melbourne, NorthWest Acad Ctr, Western Hlth, St Albans, Vic, Australia
[8] Victoria Univ, Coll Hlth & Biomed, Melbourne, Vic 8001, Australia
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2014年 / 306卷 / 09期
基金
英国医学研究理事会;
关键词
IUGR; glucose tolerance; insulin secretion; beta-cells; insulin sensitivity; training; physical activity; FOR-GESTATIONAL-AGE; LOW-BIRTH-WEIGHT; BETA-CELL MASS; POSTNATAL CALORIE RESTRICTION; DEPENDENT DIABETES-MELLITUS; REDUCING LITTER SIZE; LOW-PROTEIN DIET; RATS BORN SMALL; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
D O I
10.1152/ajpendo.00456.2013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Individuals born after intrauterine growth restriction (IUGR) are at an increased risk of developing diabetes in their adult life. IUGR impairs beta-cell function and reduces beta-cell mass, thereby diminishing insulin secretion. IUGR also induces insulin resistance, with impaired insulin signaling in muscle in adult humans who were small for gestational age (SGA) and in rodent models of IUGR. There is epidemiological evidence in humans that exercise in adults can reduce the risk of metabolic disease following IUGR. However, it is not clear whether adult IUGR individuals benefit to the same extent from exercise as do normal-birth-weight individuals, as our rat studies suggest less of a benefit in those born IUGR. Importantly, however, there is some evidence from studies in rats that exercise in early life might be able to reverse or reprogram the long-term metabolic effects of IUGR. Studies are needed to address gaps in current knowledge, including determining the mechanisms involved in the reprogramming effects of early exercise in rats, whether exercise early in life or in adulthood has similar beneficial metabolic effects in larger animal models in which insulin resistance develops after IUGR. Human studies are also needed to determine whether exercise training improves insulin secretion and insulin sensitivity to the same extent in IUGR adults as in control populations. Such investigations will have implications for customizing the recommended level and timing of exercise to improve metabolic health after IUGR.
引用
收藏
页码:E999 / E1012
页数:14
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