Increased weight and blood pressure in adolescent male offspring to mothers with pre-pregnancy diabetes - a genetic link?

被引:4
作者
Nilsson, PM [1 ]
机构
[1] Univ Lund, Dept Community Hlth Sci, S-22354 Lund, Sweden
关键词
birth weight; blood pressure; diabetes; foetal; genetic;
D O I
10.1038/sj.jhh.1000819
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Adverse factors acting in foetal or early life have been proposed to be causally related to the development of hypertension and glucose intolerance in adult life. This might be caused by the influence of foetal malnutrition and impaired foetal growth. Another explanation would be that genetic factors can cause a chain of events, leading from disease in the mother, to impaired placental function and later development of disease in the offspring, We investigated the pregnancy outcome in male offspring of 368 diabetic and 38 hypertensive mothers, all diagnosed before pregnancy, compared to the offspring of 143 254 mothers without a corresponding pre-pregnancy diagnosis. The offspring were re-investigated at the age of 18 years, at the time of a conscript test for military service, Offspring to diabetic mothers were shorter, but not thinner, and born after a shorter gestational time, than offspring to non-diabetic mothers. The former also showed increased weight and blood pressure at the conscript testing. This supports the notion of a genetic influence on birth variables as well as bodily development in the late adolescence, Thus, not only foetal malnutrition but also genetic programming seem to be factors of importance for the relationship between impaired foetal growth and adult health.
引用
收藏
页码:793 / 795
页数:3
相关论文
共 18 条
[1]   TYPE 2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS, HYPERTENSION AND HYPERLIPEMIA (SYNDROME-X) - RELATION TO REDUCED FETAL GROWTH [J].
BARKER, DJP ;
HALES, CN ;
FALL, CHD ;
OSMOND, C ;
PHIPPS, K ;
CLARK, PMS .
DIABETOLOGIA, 1993, 36 (01) :62-67
[2]   GROWTH INUTERO, BLOOD-PRESSURE IN CHILDHOOD AND ADULT LIFE, AND MORTALITY FROM CARDIOVASCULAR-DISEASE [J].
BARKER, DJP ;
OSMOND, C ;
GOLDING, J ;
KUH, D ;
WADSWORTH, MEJ .
BRITISH MEDICAL JOURNAL, 1989, 298 (6673) :564-567
[3]  
BARKER DJP, 1992, J HYPERTENS, V10, pS39
[4]   A QUALITY STUDY OF A MEDICAL BIRTH REGISTRY [J].
CNATTINGIUS, S ;
ERICSON, A ;
GUNNARSKOG, J ;
KALLEN, B .
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1990, 18 (02) :143-148
[5]   Birth weight and adult hypertension, diabetes mellitus, and obesity in US men [J].
Curhan, GC ;
Willett, WC ;
Rimm, EB ;
Spiegelman, D ;
Ascherio, AL ;
Stampfer, MJ .
CIRCULATION, 1996, 94 (12) :3246-3250
[6]   SECULAR TRENDS IN THE EFFECT OF SOCIOECONOMIC-FACTORS ON BIRTH-WEIGHT AND INFANT SURVIVAL IN SWEDEN [J].
ERICSON, A ;
ERIKSSON, M ;
KALLEN, B ;
ZETTERSTROM, R .
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1993, 21 (01) :10-16
[7]   LOW BIRTH-WEIGHT AND RISK OF HIGH BLOOD-PRESSURE IN ADULTHOOD [J].
GENNSER, G ;
RYMARK, P ;
ISBERG, PE .
BMJ-BRITISH MEDICAL JOURNAL, 1988, 296 (6635) :1498-1500
[8]   Effect of uncomplicated chronic hypertension on the risk of small-for-gestational age birth [J].
Haelterman, E ;
Breart, G ;
ParisLlado, J ;
Dramaix, M ;
Tchobroutsky, C .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1997, 145 (08) :689-695
[9]   FETAL AND INFANT GROWTH AND IMPAIRED GLUCOSE-TOLERANCE AT AGE 64 [J].
HALES, CN ;
BARKER, DJP ;
CLARK, PMS ;
COX, LJ ;
FALL, C ;
OSMOND, C ;
WINTER, PD .
BMJ-BRITISH MEDICAL JOURNAL, 1991, 303 (6809) :1019-1022
[10]  
Himmelmann Kate, 1996, Blood Pressure, V5, P278, DOI 10.3109/08037059609078060