Dementia Predictors in Parkinson Disease: A Validation Study

被引：43

作者：

Anang, Julius B. M. ^{[1
]}

Nomura, Takashi ^{[2
]}

Romenets, Silvia Rios ^{[1
]}

Nakashima, Kenji ^{[2
]}

Gagnon, Jean-Francois ^{[3
,4
]}

Postuma, Ronald B. ^{[1
,3
]}

机构：

[1] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[2] Tottori Univ, Fac Med, Div Neurol, Dept Brain & Neurosci, Tottori, Japan

[3] Hop Sacre Coeur, Ctr Etud Avancees Med Sommeil, Montreal, PQ, Canada

[4] Univ Quebec, Dept Psychol, Montreal, PQ, Canada

来源：

JOURNAL OF PARKINSONS DISEASE | 2017年 / 7卷 / 01期

基金：

加拿大健康研究院;

关键词：

Dementia; prediction; REM sleep behavior disorder; mild cognitive impairment; SLEEP BEHAVIOR DISORDER; 5-YEAR FOLLOW-UP; PROSPECTIVE COHORT; COGNITIVE DECLINE; NONMOTOR SYMPTOMS;

D O I：

10.3233/JPD-160925

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.

引用

页码：159 / 162

页数：4

共 14 条

[1] The Epidemiology of Dementia Associated with Parkinson's Disease [J].

Aarsland, Dag ;

Kurz, Martin Wilhelm .

BRAIN PATHOLOGY, 2010, 20 (03) :633-639

[2] Predictors of dementia in Parkinson disease A prospective cohort study [J].

Anang, Julius B. M. ;

Gagnon, Jean-Francois ;

Bertrand, Josie-Anne ;

Romenets, Silvia Rios ;

Latreille, Veronique ;

Panisset, Michel ;

Montplaisir, Jacques ;

Postuma, Ronald B. .

NEUROLOGY, 2014, 83 (14) :1253-1260

[3] Cognitive function in the early phase of Parkinson's disease, a five-year follow-up [J].

Domellof, M. E. ;

Ekman, U. ;

Forsgren, L. ;

Elgh, E. .

ACTA NEUROLOGICA SCANDINAVICA, 2015, 132 (02) :79-88

[4] Diagnostic procedures for Parkinson's disease dementia: Recommendations from the Movement Disorder Society Task Force [J].

Dubois, Bruno ;

Burn, David ;

Goetz, Christopher ;

Aarsland, Dag ;

Brown, Richard G. ;

Broe, Gerald A. ;

Dickson, Dennis ;

Duyckaerts, Charles ;

Cummings, Jefferey ;

Gauthier, Serge ;

Korczyn, Amos ;

Lees, Andrew ;

Levy, Richard ;

Litvan, Irene ;

Mizuno, Yoshikuni ;

McKeith, Ian G. ;

Olanow, C. Warren ;

Poewe, Werner ;

Sampaio, Cristina ;

Tolosa, Eduardo ;

Emre, Murat .

MOVEMENT DISORDERS, 2007, 22 (16) :2314-2324

[5] New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression A Prospective Cohort Comparison With Other Phenotypes [J].

Fereshtehnejad, Seyed-Mohammad ;

Romenets, Silvia Rios ;

Anang, Julius B. M. ;

Latreille, Veronique ;

Gagnon, Jean-Francois ;

Postuma, Ronald B. .

JAMA NEUROLOGY, 2015, 72 (08) :863-873

[6] Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia [J].

Gomperts, Stephen N. ;

Locascio, Joseph J. ;

Rentz, Dorene ;

Santarlasci, Andrea ;

Marquie, Marta ;

Johnson, Keith A. ;

Growdon, John H. .

NEUROLOGY, 2013, 80 (01) :85-91

[7] Nonmotor Symptoms and Cognitive Decline in de novo Parkinson's Disease [J].

Kwon, Kyum-Yil ;

Kang, Sung Hoon ;

Kim, Minjik ;

Lee, Hye Mi ;

Jang, Ji Wan ;

Kim, Ju Yeon ;

Lee, Seon-Min ;

Koh, Seong-Beom .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2014, 41 (05) :597-602

[8] The montreal cognitive assessment, MoCA:: A brief screening tool for mild cognitive impairment [J].

Nasreddine, ZS ;

Phillips, NA ;

Bédirian, V ;

Charbonneau, S ;

Whitehead, V ;

Collin, I ;

Cummings, JL ;

Chertkow, H .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2005, 53 (04) :695-699

[9] Clinical significance of REM sleep behavior disorder in Parkinson's disease [J].

Nomura, Takashi ;

Inoue, Yuichi ;

Kagimura, Tatsuo ;

Nakashima, Kenji .

SLEEP MEDICINE, 2013, 14 (02) :131-135

[10] Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study [J].

Postuma, Ronald B. ;

Bertrand, Josie-Anne ;

Montplaisir, Jacques ;

Desjardins, Catherine ;

Vendette, Melanie ;

Romenets, Silvia Rios ;

Panisset, Michel ;

Gagnon, Jean-Francois .

MOVEMENT DISORDERS, 2012, 27 (06) :720-726

← 1 2 →