Update on gastroesophageal reflux disease

被引:5
作者
Serra Pueyo, Jordi [1 ]
机构
[1] Hosp Badalona Germans Trias & Pujol, CIBERehd, Unidad Motilidad & Trastornos Func Digest, Serv Aparato Digest, Barcelona, Spain
来源
GASTROENTEROLOGIA Y HEPATOLOGIA | 2014年 / 37卷 / 02期
关键词
Gastroesophageal reflux; Acid pocket; Impedance; Alginate; PROTON PUMP INHIBITORS; LOWER ESOPHAGEAL SPHINCTER; RANDOMIZED CLINICAL-TRIAL; GABA(B) AGONIST BACLOFEN; ACID POCKET; HIATUS-HERNIA; SYMPTOMS; PREVALENCE; EFFICACY; HEARTBURN;
D O I
10.1016/j.gastrohep.2013.11.001
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastroesophageal reflux disease is a highly frequent disorder classically characterized by the presence of heartburn and/or acid regurgitation that improves with drug therapy that reduces acid content in the stomach. However, especially in patients with non-erosive disease, response to proton pump inhibitors is unsatisfactory in approximately 1 out of 3 patients, and consequently, in these patients, it is important to establish a definitive diagnosis and an alternative therapeutic strategy. In the last few years, advances have been made in knowledge of the physiopathology of reflux, such as identification of the role of the acid pocket in producing reflux, technological advances that allow differentiation among acid reflux, non-acid reflux and slightly acid reflux, and advances in the treatment of reflux with drugs that attempt to act on the barrier function of the esophagogastric junction. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.
引用
收藏
页码:73 / 82
页数:10
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