Epigenetic background of neuronal fate determination

被引：20
作者：
Wen, Shu [1 ]
Li, Hong [1 ]
Liu, Jia [1 ]
机构：
[1] Dalian Med Univ, Coll Basic Med Sci, Dept Cell Biol, Dalian 116044, Liaoning, Peoples R China
来源：
PROGRESS IN NEUROBIOLOGY | 2009年 / 87卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Neural stem cell; Cell fate determination; Transcription factor; Signaling pathway; Epigenetics; DNA methylation; Histone modifications; Non-coding RNA; NEURAL STEM-CELL; NUCLEAR RECEPTOR TLX; GENOME-WIDE ANALYSIS; DNA METHYLTRANSFERASES DNMT3A; RESTRICTIVE SILENCER FACTOR; DE-NOVO METHYLTRANSFERASES; POLYCOMB GROUP PROTEINS; CENTRAL-NERVOUS-SYSTEM; HISTONE H3 LYSINE-9; LONG NONCODING RNAS;
D O I：
10.1016/j.pneurobio.2008.10.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The development of the central nervous system (CNS) starts from neural stem cells (NSCs). During this process, NSCs are specified in space- and time-related fashions, becoming spatially heterogeneous and generating a progressively restricted repertoire of cell types: neurons, astrocytes and oligodendrocytes. The processes of neurodevelopment are determined reciprocally by intrinsic and external factors which interface to program and re-program the profiling of fate-determination gene expression. Multiple signaling pathways act in a dynamic web mode to determine the fate of NSCs through modulating the activity of a distinct set of transcription factors which in turn trigger the transcription of neural fate-determination genes. Accumulating evidence reveals that during CNS development. multiple epigenetic factors regulate the activities of extracellular signaling and corresponding transcription factors in a coordinative manner, leading to the formation of a system with sophisticated structure and magic functions. This review aims to introduce recent advances in the epigenetic background of neural cell fate determination. (C) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：98 / 117
页数：20
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