Adding Insult on Injury: Immunogenic Role for Donor-derived Cell-free DNA?

被引：23
作者：
Dholakia, Shamik [1 ]
De Vlaminck, Iwijn [2 ]
Khush, Kiran K. [3 ]
机构：
[1] Univ Oxford, Nuffield Dept Surg Sci, Oxford Transplant Ctr, Oxford, England
[2] Cornell Univ, Meinig Sch Biomed Engn, Ithaca, NY USA
[3] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA USA
来源：
TRANSPLANTATION | 2020年 / 104卷 / 11期
关键词：
DANGER SIGNAL; EXTRACELLULAR HISTONES; NLRP3; INFLAMMASOME; RECOGNITION; MEDIATORS; REJECTION; RELEASE; MARKER; DEATH;
D O I：
10.1097/TP.0000000000003240
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Donor-derived cell-free DNA (dd-cfDNA) in the blood circulation is an early marker of injury in solid organ transplantation. Here, we review recent evidence that indicates that dd-cfDNA may itself be a trigger of inflammation, thereby adding insult on injury. Early unresolving molecular allograft injury measured via changes in dd-cfDNA may be an early warning sign and may therefore enable stratification of patients who are at risk of subsequent allograft injury. Considering dd-cfDNA as a continuous and clinically significant biomarker opens up the potential for new management strategies, therapeutics, and ways to quantify interventions by considering the immunological potential of dd-cfDNA.
引用
收藏
页码：2266 / 2271
页数：6
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