Polysomnographic features of early-onset depression: A meta-analysis

被引:34
作者
Augustinavicius, Jura L. S. [1 ,2 ]
Zanjani, Anosha [4 ]
Zakzanis, Konstantine K. [5 ]
Shapiro, Colin M. [1 ,2 ,3 ]
机构
[1] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 1A1, Canada
[2] Youthdale Child & Adolescent Sleep Ctr, Toronto, ON, Canada
[3] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada
[4] Univ Toronto Scarborough, Dept Psychol, Toronto, ON M1C 1A4, Canada
[5] Ctr Addict & Mental Hlth, Toronto, ON, Canada
关键词
Major depressive disorder; Sleep; Polysomnography; Sleep electroencephalography; Depression; Pediatrics; DIGITAL PERIOD ANALYSIS; REM-SLEEP MEASURES; MAJOR DEPRESSION; ELECTROENCEPHALOGRAPHIC SLEEP; TEMPORAL COHERENCE; EEG SLEEP; PSYCHIATRIC-DISORDERS; HIGH-RISK; ADOLESCENTS; CHILDREN;
D O I
10.1016/j.jad.2013.12.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Undiagnosed major depressive disorder (MDD) is associated with increased morbidity in children and adolescents. This study evaluated features of sleep macro- and microarchitecture assessed by polysomnography (PSG) as diagnostic markers for MDD in children and adolescents. Methods: MEDLINE, PSYCINFO, EMBASE and PUBMED were searched from their availability dates to March 1st, 2013. The literature search identified 932 abstracts of which 51 studies were retrieved and 28 were included in the analysis. Study design, features of sleep macro- and microarchitecture, demographic and clinical characteristics of study groups were extracted for each study. Results: There were modest differences on sleep macroarchitecture between children and adolescents with MDD and healthy controls. The most robust difference was found in sleep latency, 31% of adolescents with MDD had increased sleep latency. Age, suicidal ideation, suicidal behavior, and psychiatric comorbidities were significant predictors of sleep macroarchitecture. Modest differences were found for sleep microarchitecture, intrahemispheric and interhemispheric temporal coherence was decreased in a third of patients with MDD. Age was a significant predictor of sleep microarchitecture. Limitations: This meta-analysis is limited by the small number of studies on sleep macroarchitecture in children with MDD and studies on sleep microarchitecture overall and by the heterogeneity in methodology between studies. Conclusions: This synthetic review of the existing literature is among the largest to quantitatively assess impaired sleep as a diagnostic marker for MDD in children and adolescents. Knowledge of sleep macro- and microarchitecture in early-onset MDD may aid the clinician in developing a treatment strategy for MDD-relaLed sleep symptoms in a subset of patients. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:11 / 18
页数:8
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