Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging

被引：28

作者：

Carop, Carlos ^{[1
,2
]}

Luisa Garcia-Martin, Maria ^{[1
,3
]}

Pernia Leal, Manuel ^{[1
,2
]}

机构：

[1] Univ Malaga, BIONAND, Andalusian Ctr Nanomed & Biotechnol, Malaga 29590, Spain

[2] Univ Seville, Dept Quim Organ & Farmaceut, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain

[3] CIBER BBN, Networking Res Ctr Bioengn Biomat & Nanomed, Malaga 29590, Spain

来源：

BIOMACROMOLECULES | 2017年 / 18卷 / 05期

关键词：

MRI CONTRAST AGENTS; NANOPARTICLES; GADOLINIUM; COMPLEXES; HYDROGELS;

D O I：

10.1021/acs.biomac.7b00224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

pH-responsive nanogels (NGs) were used to prepare high efficiency magnetic resonance imaging dual T-1/T-2 contrast agents for pH imaging. The polymeric NG matrix acts as a strong polydentate ligand that chelates the Mn cations in its inner cavity generating a hybrid NG structure. The Mn chelate NG is sensitive to pH changes, such that protonation induces a change of the polymer hydration state and consequent swelling. The swollen nanogel allows water molecules to enter and interact with the Mn chelate, shortening the relaxation time (switch ON) and giving rise to positive or negative contrast on T-1-or T-2-weighted magnetic resonance images.

引用

页码：1617 / 1623

页数：7

共 26 条

[1] Fabrication and Characterization of Gd-DTPA-Loaded Chitosan-Poly(Acrylic Acid) Nanoparticles for Magnetic Resonance Imaging [J].

Ahmed, Arsalan ;

Zhang, Chao ;

Guo, Jian ;

Hu, Yong ;

Jiang, Xiqun .

MACROMOLECULAR BIOSCIENCE, 2015, 15 (08) :1105-1114

[2] Extracellular gadolinium-based contrast media: An overview [J].

Bellin, Marie-France ;

Van Der Molen, Aart J. .

EUROPEAN JOURNAL OF RADIOLOGY, 2008, 66 (02) :160-167

[3] Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging [J].

Chan, Kannie Wai-Yan ;

Wong, Wing-Tak .

COORDINATION CHEMISTRY REVIEWS, 2007, 251 (17-20) :2428-2451

[4] Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents [J].

Courant, Thomas ;

Roullin, Valerie Gaelle ;

Cadiou, Cyril ;

Callewaert, Maite ;

Andry, Marie Christine ;

Portefaix, Christophe ;

Hoeffel, Christine ;

de Goltstein, Marie Christine ;

Port, Marc ;

Laurent, Sophie ;

Vander Elst, Luce ;

Muller, Robert ;

Molinari, Michael ;

Chuburu, Francoise .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (36) :9119-9122

[5] PH imaging [J].

Gillies, RJ ;

Raghunand, N ;

Garcia-Martin, ML ;

Gatenby, RA .

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2004, 23 (05) :57-64

[6] Selected Standard Protocols for the Synthesis, Phase Transfer, and Characterization of Inorganic Colloidal Nanoparticles [J].

Huehn, Jonas ;

Carrillo-Carrion, Carolina ;

Soliman, Mahmoud G. ;

Pfeiffer, Christian ;

Valdeperez, Daniel ;

Masood, Atif ;

Chakraborty, Indranath ;

Zhu, Lin ;

Gallego, Marta ;

Yue, Zhao ;

Carril, Monica ;

Feliu, Neus ;

Escudero, Alberto ;

Alkilany, Alaaldin M. ;

Pelaz, Beatriz ;

del Pino, Pablo ;

Parak, Wolfgang J. .

CHEMISTRY OF MATERIALS, 2017, 29 (01) :399-461

[7] Large Relaxivity Enhancement of Paramagnetic Lipid Nanoparticles by Restricting the Local Motions of the GdIII Chelates [J].

Kielar, Filip ;

Tei, Lorenzo ;

Terreno, Enzo ;

Botta, Mauro .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (23) :7836-+

[8] A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle [J].

Kim, Kyoung Sub ;

Park, Wooram ;

Hu, Jun ;

Bae, You Han ;

Na, Kun .

BIOMATERIALS, 2014, 35 (01) :337-343

[9] Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis [J].

Kuo, Phillip H. ;

Kanal, Emanuel ;

Abu-Alfa, Ali K. ;

Cowper, Shawn E. .

RADIOLOGY, 2007, 242 (03) :647-649

[10] Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging [J].

Lim, Chang-Keun ;

Singh, Ajay ;

Heo, Jeongyun ;

Kim, Daehong ;

Lee, Kyung Eun ;

Jeon, Hyesung ;

Koh, Joonseok ;

Kwon, Ick-Chan ;

Kim, Sehoon .

BIOMATERIALS, 2013, 34 (28) :6846-6852

← 1 2 3 →