Hippocampal-Sparing Whole-Brain Radiotherapy for Lung Cancer

被引：18
作者：
Zhao, Ren
Kong, Wei
Shang, Jun
Zhe, Hong
Wang, Yan-Yang [1 ,2 ]
机构：
[1] Ningxia Med Univ, Gen Hosp, Dept Radiat Oncol, Ningxia 750004, Peoples R China
[2] Ningxia Med Univ, Inst Canc, Ningxia 750004, Peoples R China
来源：
CLINICAL LUNG CANCER | 2017年 / 18卷 / 02期
关键词：
Brain metastases; Cognitive function; Hippocampus; Neurotoxicity; Planning study; PROPHYLACTIC CRANIAL IRRADIATION; SIMULTANEOUS INTEGRATED BOOST; NEUROCOGNITIVE FUNCTION; METASTASES; RADIATION; AVOIDANCE; RISK; IMPAIRMENT; STRATEGIES; MANAGEMENT;
D O I：
10.1016/j.cllc.2016.09.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Brain metastases occur in 20% to 40% of lung cancer patients. Whole-brain radiotherapy (WBRT) has long been considered the treatment of choice for many patients with lung cancer, because of its wide availability, ease of delivery, and effectiveness in prolonging survival. However, WBRT is also associated with several side effects, such as decline in memory and other cognitive functions. There exists significant preclinical and clinical evidence that radiation-induced injury to the hippocampus correlates with neurocognitive decline of patients who receive WBRT. Technological advances in treatment planning and delivery facilitate the use of hippocampal-sparing (HS) WBRT as prophylactic cranial irradiation or the primary treatment modality for lung cancer patients with brain metastases. In this review, we provide a detailed and comprehensive discussion of the safety profile, techniques for hippocampus-sparing, and the clinical evidence of HS-WBRT for lung cancer patients. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：127 / 131
页数：5
相关论文
共 37 条
[1]   Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission [J].
Aupérin, A ;
Arriagada, R ;
Pignon, JP ;
Le Péchoux, C ;
Gregor, A ;
Stephens, RJ ;
Kristjansen, PEG ;
Johnson, BE ;
Ueoka, H ;
Wagner, H ;
Aisner, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (07) :476-484
[2]   Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer - Clinical implications for the subsequent management of the brain [J].
Chen, Allen M. ;
Jahan, Thierry M. ;
Jablons, David M. ;
Garcia, Joaquin ;
Larson, David A. .
CANCER, 2007, 109 (08) :1668-1675
[3]   Annual report on status of cancer in China, 2011 [J].
Chen, Wanqing ;
Zheng, Rongshou ;
Zeng, Hongmei ;
Zhang, Siwei ;
He, Jie .
CHINESE JOURNAL OF CANCER RESEARCH, 2015, 27 (01) :2-12
[4]   Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats [J].
Cramer, C. K. ;
Yoon, S. W. ;
Reinsvold, M. ;
Joo, K. M. ;
Norris, H. ;
Hood, R. C. ;
Adamson, J. D. ;
Klein, R. C. ;
Kirsch, D. G. ;
Oldham, M. .
PLOS ONE, 2015, 10 (12)
[5]   Distribution of brain metastases in relation to the hippocampus:: Implications for neurocognitive functional preservation [J].
Ghia, Amol ;
Tome, Wolfgang A. ;
Thomas, Sayana ;
Cannon, George ;
Khuntia, Deepak ;
Kuo, John S. ;
Mehta, Mineshi P. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 68 (04) :971-977
[6]   Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial [J].
Gondi, Vinai ;
Pugh, Stephanie L. ;
Tome, Wolfgang A. ;
Caine, Chip ;
Corn, Ben ;
Kanner, Andrew ;
Rowley, Howard ;
Kundapur, Vijayananda ;
DeNittis, Albert ;
Greenspoon, Jeffrey N. ;
Konski, Andre A. ;
Bauman, Glenn S. ;
Shah, Sunjay ;
Shi, Wenyin ;
Wendland, Merideth ;
Kachnic, Lisa ;
Mehta, Minesh P. .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (34) :3810-U198
[7]   Hippocampal Dosimetry Predicts Neurocognitive Function Impairment After Fractionated Stereotactic Radiotherapy for Benign or Low-Grade Adult Brain Tumors [J].
Gondi, Vinai ;
Hermann, Bruce P. ;
Mehta, Minesh P. ;
Tome, Wolfgang A. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 85 (02) :348-354
[8]   Why avoid the hippocampus? A comprehensive review [J].
Gondi, Vinai ;
Tome, Wolfgang A. ;
Mehta, Minesh P. .
RADIOTHERAPY AND ONCOLOGY, 2010, 97 (03) :370-376
[9]   HIPPOCAMPAL-SPARING WHOLE-BRAIN RADIOTHERAPY: A "HOW-TO" TECHNIQUE USING HELICAL TOMOTHERAPY AND LINEAR ACCELERATOR-BASED INTENSITY-MODULATED RADIOTHERAPY [J].
Gondi, Vinai ;
Tolakanahalli, Ranjini ;
Mehta, Minesh P. ;
Tewatia, Dinesh ;
Rowley, Howard ;
Kuo, John S. ;
Khuntia, Deepak ;
Tome, Wolfgang A. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (04) :1244-1252
[10]   Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933 [J].
Gondi, Vinai ;
Tome, Wolfgang A. ;
Marsh, James ;
Struck, Aaron ;
Ghia, Amol ;
Turian, Julius V. ;
Bentzen, Soren M. ;
Kuo, John S. ;
Khuntia, Deepak ;
Mehta, Minesh P. .
RADIOTHERAPY AND ONCOLOGY, 2010, 95 (03) :327-331
1234