Extracellular DNA NET-Works With Dire Consequences for Health

被引:164
作者
Sorvillo, Nicoletta [1 ,3 ]
Cherpokova, Deya [1 ,3 ]
Martinod, Kimberly [4 ,5 ]
Wagner, Denisa D. [1 ,2 ,3 ]
机构
[1] Boston Childrens Hosp, Program Cellular & Mol Med, 1 Blackfan Cir,9th Floor, Boston, MA 02115 USA
[2] Boston Childrens Hosp, Div Hematol Oncol, Boston, MA USA
[3] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
[4] KU Leuven Campus Kulak Kortrijk, Lab Thrombosis Res, Kortrijk, Belgium
[5] Katholieke Univ Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Leuven, Belgium
基金
欧盟地平线“2020”; 美国国家卫生研究院;
关键词
autoimmunity; cardiovascular disease; fibrosis; inflammation; neutrophils; DEEP-VEIN THROMBOSIS; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; PEPTIDYLARGININE DEIMINASE TYPE-4; ISCHEMIA-REPERFUSION INJURY; ABDOMINAL AORTIC-ANEURYSM; TRAP FORMATION; VENOUS THROMBOEMBOLISM; NEUTROPHIL ELASTASE; TISSUE FACTOR; CYTOKINE PRODUCTION;
D O I
10.1161/CIRCRESAHA.119.314581
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neutrophils play a central role in innate immune defense. Advances in neutrophil biology have brought to light the capacity of neutrophils to release their decondensed chromatin and form large extracellular DNA networks called neutrophil extracellular traps (NETs). NETs are produced in response to many infectious and noninfectious stimuli and, together with fibrin, block the invasion of pathogens. However, their formation in inflamed blood vessels produces a scaffold that supports thrombosis, generates neo-antigens favoring autoimmunity, and aggravates damage in ischemia/reperfusion injury. NET formation can also be induced by cancer and promotes tumor progression. Formation of NETs within organs can be immediately detrimental, such as in lung alveoli, where they affect respiration, or they can be harmful over longer periods of time. For example, NETs initiate excessive deposition of collagen, resulting in fibrosis, thus likely contributing to heart failure. Here, we summarize the latest knowledge on NET generation and discuss how excessive NET formation mediates propagation of thrombosis and inflammation and, thereby, contributes to various diseases. There are many ways in which NET formation could be averted or NETs neutralized to prevent their detrimental consequences, and we will provide an overview of these possibilities.
引用
收藏
页码:470 / 488
页数:19
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