Mechanisms of gene silencing by double-stranded RNA

被引：1876

作者：

Meister, G ^{[1
]}

Tuschl, T ^{[1
]}

机构：

[1] Rockefeller Univ, Lab RNA Mol Biol, New York, NY 10021 USA

来源：

NATURE | 2004年 / 431卷 / 7006期

关键词：

D O I：

10.1038/nature02873

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterised, but a more complete understanding of the process is imminent.

引用

页码：343 / 349

页数：7

共 98 条

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