Reinfection and relapse in early Lyme disease

被引:36
作者
Krause, Peter J.
Foley, Daniel T.
Burke, Georgine S.
Christianson, Diane
Closter, Linda
Spielman, Andrew
机构
[1] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT 06106 USA
[2] Univ Connecticut, Sch Med, Hartford, CT 06112 USA
[3] Yale Univ, Sch Publ Hlth, New Haven, CT USA
[4] Block Isl Med Ctr, Block Isl, RI 02807 USA
[5] Harvard Univ, Sch Publ Hlth, Div Trop Publ Hlth, Boston, MA 02115 USA
关键词
D O I
10.4269/ajtmh.2006.75.1090
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To determine whether recurrent episodes of appropriately treated Lyme disease are caused by reinfection or relapse, we monitored pertinent clinical manifestations and serology of residents of an endemic site each year for 14 years. Of 253 episodes of early Lyme disease recorded among 213 residents, we observed 40 recurrent episodes. Virtually all included an erythema migrans (EM) rash that appeared at body sites that differed from those of the initial rash, no subjects produced detectable levels of specific antibody between sequential episodes, all episodes occurred a year or more after the initial EM episode, and all occurred during late spring and early summer. People experiencing recurrent episodes tended to have frequent contact with vector ticks. Prompt administration of standard antibiotic therapy for early Lyme disease reliably eliminates persistent infection and prevents relapse.
引用
收藏
页码:1090 / 1094
页数:5
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