Oncothermia Treatment of Cancer: From the Laboratory to Clinic

被引:52
作者
Andocs, G. [1 ]
Szasz, O. [2 ]
Szasz, A. [2 ]
机构
[1] St Istvan Univ, Dept Pharmacol & Toxicol, Budapest, Hungary
[2] St Istvan Univ, Dept Biotech, Budapest, Hungary
关键词
Cancer; Hyperthermia; Oncothermia; Electric-field; In-vivo; In-vitro; Clinical; HYPERTHERMIA; RADIOTHERAPY; TRIAL;
D O I
10.1080/15368370902724633
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Oncothermia is a long-time applied method (since 1989) in oncology. Its clinical results excellently show its advantages, however the details of its mechanism are under investigation even today. The method is based on a self-selective process of energy concentration and targets the membrane of the malignant cell, using the temperature gradient and the beta-dispersion of the membrane proteins. To prove the theory we show the experimental evidences in vitro experiments where we showed the definite difference between the conventional heating and the oncothermia at the same temperature. In the next step, we studied some xenograft nude-mice models, verifying the temperature-dependent and non temperature dependent factors. In addition, the synergic effect with some chemotherapies were studied, having more efficacy of the oncothermia with drugs than the conventional heating. These experiments show the definite advantages of the oncothermia Compared to its classical counterpart, acting on the same temperature. We have also proved the beneficial effect of oncothermia treatment in the veterinary practice Oncothermia is applied in numerous clinics and hospitals, and we would like to show some characteristic case-reports and also the clinical benefit on the survival time elongation of liver-, pancreas-, brain-, and lung-tumor-lesions.
引用
收藏
页码:148 / 165
页数:18
相关论文
共 75 条
[31]  
Hand J., 1993, INTERSTITIAL INTRACA, P83
[32]  
HORNBACK ND, 1984, HYPERTHERMIA CANC HU
[33]  
KLEEF R, 2004, ICHS C SHENZH CHIN
[34]  
Kosaka M., 2001, Thermotherapy for Neoplasia, Inflammation, and Pain
[35]  
Matsuda T., 1993, Cancer Treatment by Hyperthermia, Radiation and Drugs
[36]   A future for hyperthermia in cancer treatment? [J].
Nielsen, OS ;
Horsman, M ;
Overgaard, J .
EUROPEAN JOURNAL OF CANCER, 2001, 37 (13) :1587-1589
[37]  
OSINSKY S, 2004, LOCAL REGIONAL HYPER
[38]  
PANAGIOTOU P, 2005, GEN M EUR SOC HYP ON
[39]  
Perez C.A., 2004, Principles and practice of radiation oncology
[40]  
RENNER H, 2007, COMMUNICATION