Dolutegravir Cerebrospinal Fluid Diffusion in HIV-1-Infected Patients with Central Nervous System Impairment

被引：15
|
作者：
Gele, Thibaut [1 ,2 ]
Furlan, Valerie [3 ]
Taburet, Anne-Marie [2 ]
Pallier, Coralie [4 ]
Becker, Pierre-Hadrien [5 ]
Goujard, Cecile [6 ,7 ,8 ]
Gasnault, Jacques [2 ,6 ]
Barrail-Tran, Aurelio [1 ,2 ,9 ]
Cheret, Antoine [6 ,10 ]
机构：
[1] Hop Univ Paris Sud, Hop Mitre, AP HP, Dept Clin Pharm, Le Kremlin Bicetre, France
[2] Paris Sud Univ, CEA, INSERM U1184, IDMIT Infrastruct, Fontenay Aux Roses, France
[3] Hop Univ Paris Sud, Hop Bicetre, AP HP, Dept Pharmacol, Le Kremlin Bicetre, France
[4] Hop Univ Paris Sud, Hop Paul Brousse, AP HP, Dept Virol, Villejuif, France
[5] Hop Univ Paris Sud, Hop Bicetre, AP HP, Dept Biochem, Le Kremlin Bicetre, France
[6] Hop Univ Paris Sud, Hop Bicetre, AP HP, Dept Internal Med, Le Kremlin Bicetre, France
[7] Paris Sud Univ, CESP, INSERM U1018, Villejuif, France
[8] Paris Sud Univ, Coll Med, Le Kremlin Bicetre, France
[9] Paris Sud Univ, Coll Pharm, Chatenay Malabry, France
[10] Paris Descartes Univ, INSERM U1016, CNRS 8104, Inst Cochin, Paris, France
来源：
OPEN FORUM INFECTIOUS DISEASES | 2019年 / 6卷 / 06期
关键词：
cerebrospinal fluid; central nervous system diffusion; central nervous system impairment; dolutegravir; pharmacokinetics; ANTIVIRAL ACTIVITY;
D O I：
10.1093/ofid/ofz174
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study aimed to determine dolutegravir cerebrospinal fluid (CSF) diffusion in 13 patients with HIV-related cerebral impairment enrolled in a real-life observational study. Dolutegravir median (range) CSF concentration [9.6 (3.6-22.8) ng/mL] reached CSF therapeutic concentrations whatever the blood-brain barrier status and diffused in correlation with the albumin quotient (P =.0186).
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收藏
页数：4
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