The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7

被引：72

作者：

Behrensdorf, HA

van de Craen, M

Knies, UE

Vandenabeele, P

Clauss, M

机构：

[1] Max Planck Inst Physiol & Clin Res, Dept Mol Cell Biol, D-61231 Bad Nauheim, Germany

[2] Flanders Interuniv, Inst Biotechnol, Dept Biol Mol, B-9000 Ghent, Belgium

[3] State Univ Ghent, B-9000 Ghent, Belgium

来源：

FEBS LETTERS | 2000年 / 466卷 / 01期

关键词：

endothelial monocyte-activating polypeptide II; caspase-7; apoptosis; leukocyte recruitment;

D O I：

10.1016/S0014-5793(99)01777-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. (C) 2000 Federation of European Biochemical Societies.

引用

页码：143 / 147

页数：5

共 20 条

[1] Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver [J].