Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis

被引：26

作者：

Branco de Barros, Andre Luis ^{[1
]}

Cardoso, Valbert Nascimento ^{[1
]}

Mota, Luciene das Gracas ^{[1
]}

Leite, Elaine Amaral ^{[1
]}

de Oliveira, Monica Cristina ^{[1
]}

Alves, Ricardo Jose ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, BR-31279901 Belo Horizonte, MG, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 09期

关键词：

Glucose; Technetium-99m; MAG(3); Tumor; Diagnosis agents; POSITRON-EMISSION-TOMOGRAPHY; CELL-PROLIFERATION; NUCLEAR-MEDICINE; INFLAMMATION; ONCOLOGY; INFECTION; UPDATE; PET;

D O I：

10.1016/j.bmcl.2009.03.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A D-glucose-MAG3 derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, Dglucose-MAG(3) is a potential agent for tumor diagnosis. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2497 / 2499

页数：3

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