Periodontitis is related to lung volumes and airflow Limitation: a cross-sectional study

被引：26

作者：

Holtfreter, Birte ^{[1
]}

Richter, Stefanie ^{[1
]}

Kocher, Thomas ^{[1
]}

Doerr, Marcus ^{[2
]}

Voelzke, Henry ^{[3
]}

Ittermann, Till ^{[3
]}

Obst, Anne ^{[2
]}

Schaeper, Christoph ^{[2
]}

John, Ulrich ^{[4
]}

Meisel, Peter ^{[1
]}

Grotevendt, Anne ^{[5
]}

Felix, Stephan B. ^{[2
]}

Ewert, Ralf ^{[2
]}

Glaeser, Sven ^{[2
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Dept Restorat Dent Periodontol & Endodontol, Univ Med, Unit Periodontol, D-17475 Greifswald, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, Univ Med, D-17475 Greifswald, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Inst Community Med, Study Hlth Pomerania SHIP Clin Epidemiol Res, D-17475 Greifswald, Germany

[4] Ernst Moritz Arndt Univ Greifswald, Inst Epidemiol & Social Med, Univ Med, D-17475 Greifswald, Germany

[5] Ernst Moritz Arndt Univ Greifswald, Inst Clin Chem & Lab Med, Univ Med, D-17475 Greifswald, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2013年 / 42卷 / 06期

关键词：

C-REACTIVE PROTEIN; VENTILATOR-ASSOCIATED PNEUMONIA; OBSTRUCTIVE PULMONARY-DISEASE; MULTIPLE IMPUTATION; CIGARETTE-SMOKING; BIRTH-WEIGHT; HEALTH; ASSOCIATION; STANDARDIZATION; INFLAMMATION;

D O I：

10.1183/09031936.00109112

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25-86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p<0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth. Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases.

引用

页码：1524 / 1535

页数：12

共 62 条

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