Fluoroquinolone-metal complexes: A route to counteract bacterial resistance?

被引：49

作者：

Feio, Maria J. ^{[1
]}

Sousa, Isabel ^{[1
]}

Ferreira, Mariana ^{[1
]}

Cunha-Silva, Luis ^{[1
]}

Saraiva, Raul G. ^{[1
]}

Queiros, Carla ^{[1
]}

Alexandre, Jose G. ^{[1
]}

Claro, Vasco ^{[1
]}

Mendes, Adelia ^{[1
]}

Ortiz, Rosa ^{[2
]}

Lopes, Sandra ^{[1
]}

Amaral, Ana Luisa ^{[1
]}

Lino, Joao ^{[1
]}

Fernandes, Patricia ^{[1
]}

Silva, Ana Joao ^{[1
]}

Moutinho, Lisete ^{[1
]}

de Castro, Baltazar ^{[1
]}

Pereira, Eulalia ^{[1
]}

Perello, Lourdes ^{[2
]}

Gameiro, Paula ^{[1
]}

机构：

[1] Univ Porto, Dept Quim & Bioquim, REQUIMTE, Fac Ciencias, P-4169007 Oporto, Portugal

[2] Univ Valencia, Fac Farm, Dept Quim Inorgan, Valencia 46100, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2014年 / 138卷

关键词：

Fluoroquinolones; Metalloantibiotics; Bacterial resistance; Solution equilibria; INTRAMOLECULAR STACKING INTERACTIONS; RAY STRUCTURAL CHARACTERIZATION; ESCHERICHIA-COLI-B; PHYSICOCHEMICAL PROPERTIES; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURES; TERNARY COMPLEXES; SPECTROSCOPIC CHARACTERIZATION;

D O I：

10.1016/j.jinorgbio.2014.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbial resistance to antibiotics is one of the biggest public health threats of the modem world. Antibiotic resistance is an area of much clinical relevance and therefore research that has the potential to identify agents that may circumvent it or treat resistant infections is paramount. Solution behavior of various fluoroquinolone (FQ) complexes with copper(II) in the presence and absence of 1,10-phenanthroline (phen) was studied in aqueous solution, by potentiometry and/or spectrophotometiy, and are herein described. The results obtained showed that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):FQ:phen ternary complexes are stable. Hence, these complexes were synthesised and characterised by means of UV-visible and IR spectroscopy, elemental analysis and single-crystal X-ray diffraction. In these complexes, the FQ acts as a bidentate ligand that coordinates the metal cation through the carbonyl and carboxyl oxygen atoms and phen coordinates through two N-atoms forming the equatorial plane of a distorted square-pyramidal geometry. The fifth position of the penta-coordinated Cu(II) centre is generally occupied axially by an oxygen atom from a water molecule or from a nitrate ion. Minimum inhibitory concentration (MIC) determinations of the complexes and comparison with free FQ in various E. coli strains indicate that the Cu-complexes are as efficient antimicrobials as the free antibiotic. Moreover, results strongly suggest that the cell intake route of both species is different supporting, therefore, the complexes' suitability as candidates for further biological testing in FQ-resistant microorganisms. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：129 / 143

页数：15

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