Polymorphism in cocrystals: a review and assessment of its significance

被引：255

作者：

Aitipamula, Srinivasulu ^{[1
]}

Chow, Pui Shan ^{[1
]}

Tan, Reginald B. H. ^{[1
,2
]}

机构：

[1] ASTAR, Inst Chem & Engn Sci, Singapore 627833, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

CRYSTENGCOMM | 2014年 / 16卷 / 17期

关键词：

DISSOLVING EUTECTIC COMPOSITIONS; CRYSTAL-STRUCTURE PREDICTION; MULTIPLE-COMPONENT CRYSTALS; ACID CO-CRYSTALS; PHARMACEUTICAL COCRYSTALS; CONFORMATIONAL POLYMORPHISM; PHYSICOCHEMICAL PROPERTIES; TAUTOMERIC POLYMORPHISM; CONCOMITANT POLYMORPHS; 4-HYDROXYBENZOIC ACID;

D O I：

10.1039/c3ce42008f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cocrystals have gained much interest in recent years owing to their potential to improve the physicochemical properties of the parent compounds. It was once thought that cocrystals could be a means to prevent polymorphism but many recent examples of cocrystal polymorphism have been discovered and reported. Similar to single component crystals, polymorphs of cocrystals can display significantly different properties. In this contribution, we present a survey of polymorphic cocrystals. The different types of polymorphs, namely synthon, conformational, packing, and tautomeric, are identified and discussed with representative examples. In addition, polymorphs of cocrystals that showed distinct physicochemical properties are highlighted.

引用

页码：3451 / 3465

页数：15

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