Cortical microinfarcts in patients with multiple lobar microbleeds on 3T MRI

被引：20

作者：

Ii, Yuichiro ^{[1
]}

Maeda, Masayuki ^{[2
]}

Ishikawa, Hidehiro ^{[1
]}

Ito, Ai ^{[1
]}

Matsuo, Ko ^{[1
]}

Umino, Maki ^{[3
]}

Shindo, Akihiro ^{[1
]}

Kida, Hirotaka ^{[4
]}

Satoh, Masayuki ^{[4
]}

Niwa, Atsushi ^{[1
]}

Taniguchi, Akira ^{[1
]}

Tomimoto, Hidekazu ^{[1
]}

机构：

[1] Mie Univ, Dept Neurol, Sch Med, 2-174 Edobashi, Tsu, Mie 5148507, Japan

[2] Mie Univ, Dept Adv Diagnost Imaging, Grad Sch Med, Tsu, Mie, Japan

[3] Mie Univ, Dept Radiol, Grad Sch Med, Tsu, Mie, Japan

[4] Mie Univ, Dept Dementia Prevent & Therapeut, Grad Sch Med, Tsu, Mie, Japan

来源：

JOURNAL OF NEUROLOGY | 2019年 / 266卷 / 08期

基金：

日本学术振兴会;

关键词：

Cortical microinfarcts; Cerebral microbleeds; Cerebral amyloid angiopathy; Hypertensive vasculopathy; Cortical superficial siderosis; Magnetic resonance imaging; CEREBRAL AMYLOID ANGIOPATHY; SMALL VESSEL DISEASE; 7.0-TESLA MAGNETIC-RESONANCE; SUPERFICIAL SIDEROSIS; VASCULAR DEMENTIA; ALZHEIMER-DISEASE; IN-VIVO; RATING-SCALE; MICROANGIOPATHY; HISTOPATHOLOGY;

D O I：

10.1007/s00415-019-09350-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pathogenesis of cortical microinfarcts (CMIs) is considered to be heterogeneous including cerebral small vessel disease (SVD) such as hypertensive vasculopathy (HV) and cerebral amyloid angiopathy (CAA). Recent advances in MRI have enabled the detection of CMIs in vivo. To investigate the characteristics of CMIs in advanced cerebral SVD, we performed a retrospective analysis of 85 patients with cognitive impairment who had multiple lobar cerebral microbleeds (CMBs) on 3T MRI. Among them, 41 (48.2%) patients were classified into the strictly lobar CMB group (i.e. probable-CAA group), and 44 (51.8%) patients were classified into the non-lobar with lobar CMBs group (i.e. mix-CMBs group). The relationship between CMIs and CMBs, cortical superficial siderosis (cSS) and white matter hyperintensity was evaluated. Nine of the 41 (22.0%) patients with probable-CAA had a total of 19 CMIs, while 12 of the 44 (27.3%) patients with mix-CMBs had a total of 38 CMIs. In the probable-CAA group, the presence of CMIs was significantly associated with the presence of cSS (p < 0.001). In addition, a close spatial association between CMIs and cSS was observed. On the contrary, in the mix-CMB group, the presence of CMIs was significantly associated with the number of lobar CMBs in the frontal lobe (p = 0.034). Our results suggest that CMIs in the probable-CAA may be attributable to more severe CAA, while CMIs in the mix-CMBs indicate an advanced HV, especially when observed with more numerous lobar CMBs.

引用

页码：1887 / 1896

页数：10

共 47 条

[1] The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts [J].