Phase behavior study of paclitaxel loaded amphiphilic copolymer in two solvents by dissipative particle dynamics simulations

被引：32
作者：
Guo, Xin Dong [1 ,2 ]
Tan, Jeremy Pang Kern [1 ]
Zhang, Li Juan [2 ]
Khan, Majad [1 ]
Liu, Shao Qiong [3 ]
Yang, Yi Yan [1 ]
Qian, Yu [2 ]
机构：
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China
[3] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119077, Singapore
来源：
CHEMICAL PHYSICS LETTERS | 2009年 / 473卷 / 4-6期
基金：
中国国家自然科学基金;
关键词：
ACID) BLOCK-COPOLYMERS; DIBLOCK COPOLYMERS; MESOSCOPIC SIMULATION; MORPHOLOGICAL TRANSITIONS; MICROPHASE SEPARATION; MOLECULAR-DYNAMICS; DILUTE-SOLUTION; DRUG-DELIVERY; MICELLES; NANOPARTICLES;
D O I：
10.1016/j.cplett.2009.04.009
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
DPD simulations were employed to study the phase behavior of paclitaxel loaded PEO11-b-PLLA(9) in water and N,N-Dimethylformamide. Different ordered structures were observed in water-rich solvents. All the structures were greatly affected by solvents compositions. By varying the fractions of each component, a phase diagram of paclitaxel loaded PEO11-b-PLLA(9) in water and DMF was mapped. For all ordered structures, bicontinuous, lamella, rod, and spherical structures with different sizes could be easily observed for their wide distribution in the phase diagram. While the HPL, dumbbell, and spherical structures with uniform size were difficult to be obtained, due to their narrow distribution. (c) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：336 / 342
页数：7
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