Combination chemotherapy with irinotecan and adriamycin for refractory and relapsed non-Hodgkin's lymphoma

被引：22

作者：

Saotome, T

Takagi, T

Sakai, C

Kumagai, K

Tamaru, J

机构：

[1] Chiba Canc Ctr Hosp, Div Hematol Oncol, Chuo Ku, Chiba 2600801, Japan

[2] Saitama Med Sch, Saitama Med Ctr, Dept Pathol, Saitama, Japan

来源：

ANNALS OF ONCOLOGY | 2000年 / 11卷 / 01期

关键词：

adriamycin; irinotecan hydrochloride (CPT-11); non-Hodgkin's lymphoma; salvage chemotherapy;

D O I：

10.1023/A:1008368905546

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-five patients with relapsed or refractory non-Hodgkin's lymphoma were treated by combination chemotherapy with irinotecan hydrochloride (CPT-11) and adriamycin (ADM): CPT-11, 25 mg/m(2) on days 1 and 2; ADM, 40 mg/m(2) on day 3. Nine (36%) of twenty-five patients achieved CR. Fairly good responses were seen in relapsed B-cell lymphomas (4 of 8 in diffuse large B-cell lymphoma and 2 of 2 in follicular lymphoma grade 1), and substantial responses in T-cell lymphomas (1 of 4 in peripheral T-cell lymphoma and 2 of 7 in adult T-cell leukemia/lymphoma). Leukopenia was frequent but tolerable, and diarrhea minimal. Combination chemotherapy with a reduced dose CPT-11 and ADM was useful in the treatment of relapsed non-Hodgkin's lymphoma.

引用

页码：115 / 116

页数：2

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