Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma

被引：25

作者：

Kmiecik, Justyna ^{[1
]}

Navarro, Andrea Gras ^{[1
]}

Poli, Aurelie ^{[2
]}

Planaguma, Jesus ^{[3
]}

Zimmer, Jacques ^{[2
]}

Chekenya, Martha ^{[1
,4
]}

机构：

[1] Univ Bergen, Inst Biomed, Bergen, Norway

[2] CRP Sante, Lab Immunogenet Allergol, Luxembourg, Luxembourg

[3] Hosp Clin IDIBAPS, Dept Neuroimmunol, Barcelona, Spain

[4] Univ Bergen, Inst Clin Dent, Bergen, Norway

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

CNS immunosurveillance; CSPG4; glioblastoma; NK cells; passive immunotherapy; EXPRESSION; SURVIVAL;

D O I：

10.4161/onci.27185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma is a deadly brain cancer with limited treatment options. Targeting chondroitin sulfate proteoglycan 4 (CSPG4, best known as NG2) with the monoclonal antibody mAb9.2.27 and activated natural killer (NK) cells abrogated the tumor growth and prolonged the survival of glioblastoma-bearing animals by favoring the establishment of a pro-inflammatory microenvironment. The combination of NK cells and mAb9.2.27 recruited ED1(+) CCR2(low) macrophages that stimulated ED1(+) ED2(low)MHCII(high) microglial cells to exert robust cytotoxicity. Our findings demonstrate the therapeutic potential of targeting salient tumor associated-antigens.

引用

页数：3

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