The Structure of 30 nm Chromatin Fiber and Its Regulation

被引：0

作者：

Liang Dan ^{[1
]}

Chen Ping ^{[1
]}

Li Guo-Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 42卷 / 11期

基金：

中国国家自然科学基金;

关键词：

30 nm chromatin fiber; nucleosome; linker histone H1; epigenetics; NUCLEOSOME CORE PARTICLE; HISTONE H1; CRYSTAL-STRUCTURE; H4-K16; ACETYLATION; LINKER HISTONE; CRYO-EM; ORGANIZATION; REVEALS; MAINTAIN; SUPPORT;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, genomic DNA is hierarchically packed into chromatin by histones in the nucleus. Despite of over 30 years' study, the fundamental structure of 30 nm chromatin fiber remains controversial. In this review, we focus on recent progress in revealing the structure of 30 nm chromatin fiber, and emphasize on the most recent left-handed double helix structure of 30 nm chromatin fiber. In addition, we discuss the epigenetic regulation of the 30 nm chromatin structure. Finally, we discuss the possible challenge in elucidating the structure of 30 nm chromatin fiber and its regulation.

引用

页码：1009 / 1014

页数：6

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