A general Staudinger protocol for solution-phase parallel synthesis

被引：40
|
作者：
Lindsley, CW [1 ]
Zhao, Z [1 ]
Newton, RC [1 ]
Leister, WH [1 ]
Strauss, KA [1 ]
机构：
[1] Merck Res Labs, Technol Enabled Synth Grp, Dept Med Chem, W Point, PA 19486 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期
关键词：
reduction; azides; combinatorial chemistry;
D O I：
10.1016/S0040-4039(02)00827-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Staudinger reaction has been adapted for parallel synthesis by the application of fluorous-tethered triphenyl phosphine. The fluorous-tethered triphenylphosphine is expediently removed in parallel by FluoroFlash(TM) SPE columns to afford functionalized amines in high yields and purities. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4467 / 4470
页数：4
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