Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice

被引：624

作者：

Branda, CS ^{[1
]}

Dymecki, SM ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

DEVELOPMENTAL CELL | 2004年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1534-5807(03)00399-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Site-specific recombinase systems (Cre-IoxP, Flp-FRT, and phiC31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.

引用

页码：7 / 28

页数：22

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