Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine

被引：2
作者：
Nolan, Terry [1 ,2 ]
Ruff, Tilman A.
Lambert, Stephen B. [1 ,2 ]
Buttery, Jim [1 ,2 ]
O'Grady, Kerry-Ann [1 ,2 ]
Streeton, Catherine [3 ]
Hoet, Bernard [3 ]
Bock, Hans L. [3 ]
机构：
[1] Univ Melbourne, Melbourne Sch Populat Hlth, Melbourne, Vic 3010, Australia
[2] Murdoch Childrens Res Inst, Vaccine & Immunisat Res Grp, Melbourne, Vic, Australia
[3] GlaxoSmithKline, Biol, Rixensart, Belgium
来源：
VACCINE | 2009年 / 27卷 / 18期
关键词：
Acellular pertussis vaccine; Booster; Vaccination; POLIO VACCINE; IMMUNOGENICITY; REACTOGENICITY; COMBINATION; INFANCY; SAFETY;
D O I：
10.1016/j.vaccine.2009.02.065
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18-20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and >= 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016 IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：2410 / 2413
页数：4
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