Isolation and Identification of Precocenes and Piperitone from Essential Oils as Specific Inhibitors of Trichothecene Production by Fusarium graminearum

被引：39

作者：

Yaguchi, Atsushi ^{[1
]}

Yoshinari, Tomoya ^{[1
]}

Tsuyuki, Rie ^{[1
]}

Takahashi, Haruo ^{[2
]}

Nakajima, Takashi ^{[3
]}

Sugita-Konishi, Yoshiko ^{[4
]}

Nagasawa, Hiromichi ^{[1
]}

Sakuda, Shohei ^{[1
]}

机构：

[1] Univ Tokyo, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Publ Hlth Lab Chiba Prefecture, Chuo Ku, Chiba 2608715, Japan

[3] Natl Agr Res Ctr Kyushu Okinawa Reg, Kumamoto 8611192, Japan

[4] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 03期

关键词：

Deoxynivalenol; Matricaria recutita; precocene; Fusarium graminearum; piperitone; Eucalyptus dives; AFLATOXIN G(1); BIOSYNTHESIS; MYCOTOXIN; ACCUMULATION; CONSTITUENTS; STRAINS; GENE;

D O I：

10.1021/jf802813h

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Inhibitors of deoxynivalenol production by Fusarium graminearum are useful for protecting crops from deoxynivalenol contamination. We isolated precocenes and piperitone from the essential oils of Matricaria recutita and Eucalyptus dives, respectively, as specific inhibitors of the production of 3-acetyldeoxynivalenol, a biosynthetic precursor of deoxynivalenol. Precocenes I and I I and piperitone inhibited 3-acetyldeoxynivalenol production by F graminearum in a liquid culture with IC50 values of 16.6, 1.2, and 306 mu M, respectively, without inhibiting fungal growth. Precocene 11 also inhibited deoxynivalenol production by the fungus in a solid culture on rice with an IC50 value of 2.0 ppm. Precocene 11 and piperitone decreased the mRNA levels of Tri4, Tri5, Tri6, and Tri10 encoding proteins required for deoxynivalenol biosynthesis.

引用

页码：846 / 851

页数：6

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