New insights into the genetics of addiction

被引：159

作者：

Li, Ming D. ^{[1
]}

Burmeister, Margit ^{[2
,3
]}

机构：

[1] Univ Virginia, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22911 USA

[2] Univ Michigan, Mol & Behav Neurosci Inst, Dept Psychiat, Ann Arbor, MI 48019 USA

[3] Univ Michigan, Mol & Behav Neurosci Inst, Dept Human Genet, Ann Arbor, MI 48019 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; NICOTINE DEPENDENCE; ALCOHOL DEPENDENCE; LINKAGE DISEQUILIBRIUM; MICE LACKING; CANDIDATE GENE; SUBUNIT GENE; LUNG-CANCER; SUSCEPTIBILITY LOCUS; HAPLOTYPIC VARIANTS;

D O I：

10.1038/nrg2536

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Drug addiction is a common brain disorder that is extremely costly to the individual and to society. Genetics contributes significantly to vulnerability to this disorder, but identification of susceptibility genes has been slow. Recent genome-wide linkage and association studies have implicated several regions and genes in addiction to various substances, including alcohol and, more recently, tobacco. Current efforts aim not only to replicate these findings in independent samples but also to determine the functional mechanisms of these genes and variants.

引用

页码：225 / 231

页数：7

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