Electrocatalytic oxidation and selective voltammetric detection of methyldopa in the presence of hydrochlorothiazide in real samples

被引：27

作者：

Tajik, Somayeh ^{[1
,2
]}

Aflatoonian, Mohammad Reza ^{[2
,3
]}

Beitollahi, Hadi ^{[4
]}

Shoaie, Iran Sheikh ^{[5
]}

Dourandish, Zahra ^{[5
]}

Fariba, Garkani Nejad ^{[5
]}

Aflatoonian, Behnaz ^{[2
]}

Bamorovat, Mehdi ^{[3
]}

机构：

[1] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran

[2] Kerman Univ Med Sci, Neurosci Res Ctr, Kerman, Iran

[3] Kerman Univ Med Sci, Leishmaniasis Res Ctr, Kerman, Iran

[4] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Environm Dept, Kerman, Iran

[5] Shahid Bahonar Univ Kerman, Fac Sci, Dept Chem, Kerman 76175133, Iran

来源：

MICROCHEMICAL JOURNAL | 2020年 / 158卷

关键词：

Zno nanoparticles; Amplified sensor; Methyldopa; Carbon paste electrode; Hydrochlorothiazide; GLASSY-CARBON ELECTRODE; PERFORMANCE LIQUID-CHROMATOGRAPHY; DOPED DIAMOND ELECTRODE; PASTE ELECTRODE; ELECTROCHEMICAL OXIDATION; HUMAN PLASMA; GRAPHENE; SENSOR; OXIDE; QUANTIFICATION;

D O I：

10.1016/j.microc.2020.105182

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The combination of methyldopa and hydrocholorothiazide are used to treat high blood pressure. The present research dealt with the synthesis and utilization of the hexagonal-shaped of ZnO nanoparticles (NPs) to develop a new, sensitive, and exclusive electrochemical sensor for detection of methyldopa. Thus, we did our examination on the methyldopa detection via cyclic voltammetry (CV) method, differential pulse voltammetry (DPV) technique, and chronoamperometry (CH) at molybdenum (VI) complex-ionic liquid-ZnO NP modified carbon paste electrode (MCILZNMCPE) in 0.1 M PBS (pH of 7.0) solution. The use of DPV showed linear dependence of methyldopa peak current at pH of 7.0 solution on their concentration ranging between 0.05 and 300.0 mu M. Then, limit of detection (LOD) has been determined to be 20.0 nM for methyldopa. Ultimately, the modified electrode has been utilized for detecting methyldopa in the presence of hydrochlorothiazide by DPV.

引用

页数：8

共 52 条

[1]

Abdussalam-Mohammed W., 2020, ADV J CHEM A, V3, P192, DOI DOI 10.33945/SAMI/AJCA.2020.2.8

[2] Electrochemical oxidation behavior of hydrochlorothiazide on a glassy carbon electrode and its voltammetric determination in pharmaceutical formulations and biological fluids [J].