Microneedle, bio-microneedle and bio-inspired microneedle: A review

被引：325
作者：
Ma, Guojun [1 ]
Wu, Chengwei [1 ]
机构：
[1] Dalian Univ Technol, State Key Lab Struct Anal Ind Equipment, Dept Engn Mech, Int Ctr Computat Mech,Fac Vehicle Engn & Mech, Dalian 116024, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2017年 / 251卷
基金：
美国国家科学基金会;
关键词：
Microneedle; Bio-microneedle; Transdermal drug delivery; Insertion force; TRANSDERMAL DRUG-DELIVERY; HOLLOW MICRONEEDLES; IN-VIVO; HUMAN SKIN; VACCINE DELIVERY; INSERTION FORCE; MICROFABRICATED MICRONEEDLES; INFLUENZA VACCINATION; SILICON MICRONEEDLES; POLYMER MICRONEEDLES;
D O I：
10.1016/j.jconrel.2017.02.011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows themwith many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs. Secondly, researches on inserting behavior and mechanical performances of MNs are discussed. Thirdly, literatures on the drug delivery and the pain resulted from the insertion of MNs are overviewed. Finally, some bio-microneedles and bio-inspired MNs are introduced. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：11 / 23
页数：13
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