Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells

被引：115

作者：

Hsu, YL

Kuo, PL

Liu, CF

Lin, CC

机构：

[1] Kaohsiung Med Coll, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan

[3] Natl Taipei Coll Nursing, Taipei, Taiwan

来源：

CANCER LETTERS | 2004年 / 212卷 / 01期

关键词：

acacetin; A549; p53; Fas; Fas ligand; apoptosis;

D O I：

10.1016/j.canlet.2004.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we examined acacetin (5,7-dihydroxy-4-methoxyflavone), a flavonoid compound, for its effect on proliferation in human non-small cell lung cancer A549 cells. The results first reported that acacetin not only inhibited A549 cell proliferation but also induced apoptosis and blocked cell cycle progression in the G1 phase. ELISA assay demonstrated that acacetin significantly increased the expression of p53 and p21/WAF1 protein, which caused cell cycle arrest. An enhancement in Fas and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by acacetin. Taken together, p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of acacetin in A549 cells. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 60

页数：8

共 22 条

[1] Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I [J].