Organocatalytic enantioselective Michael reaction of 1,3-dicarbonyls with α-substituted β-nitroacrylates

被引：13

作者：

Chang, Hsuan-Hao ^{[1
]}

Chu, Kai-Ti ^{[2
]}

Chiang, Ming-Hsi ^{[2
]}

Han, Jeng-Liang ^{[1
]}

机构：

[1] Chung Yuan Christian Univ, Dept Chem, 200 Chung Pei Rd, Taoyuan 32023, Taiwan

[2] Acad Sinica, Inst Chem, Taipei 11529, Taiwan

来源：

TETRAHEDRON | 2017年 / 73卷 / 06期

关键词：

Asymmetric Michael reaction; 1,3-Dicarbonyls; alpha-Substituted-beta-nitroacrylates; Isoxazole ring; Organocatalysis; STEREOSELECTIVE-SYNTHESIS; BETA(2,2)-AMINO ACIDS; CONJUGATE ADDITION; BUILDING-BLOCKS; CONSTRUCTION; AMINO; NITROALKENES; HYDROGENATION; DERIVATIVES; PEPTIDES;

D O I：

10.1016/j.tet.2016.12.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient asymmetric Michael reaction of 1,3-dicarbonyl compounds with alpha-Substituted-beta-Nitro-acrylates has been developed by using a cinchona-thiourea bifunctional organocatalyst in high yields and enantioselectivies. One of adducts could be transformed into a chiral 1i-nitroester bearing an isoxazole skeleton and an all-carbon quaternary chiral center. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：727 / 734

页数：8

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