Development and Function of the Drosophila Tracheal System

被引：67
作者：
Hayashi, Shigeo [1 ,2 ]
Kondo, Takefumi [3 ,4 ]
机构：
[1] RIKEN, Ctr Dev Biol, Lab Morphogenet Signaling, Kobe, Hyogo 6500047, Japan
[2] Kobe Univ, Grad Sch Sci, Dept Biol, Nada Ku, Kobe, Hyogo 6578501, Japan
[3] Kyoto Univ, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068501, Japan
[4] Keihanshin Consortium Fostering Next Generat Glob, Kyoto 6068501, Japan
来源：
GENETICS | 2018年 / 209卷 / 02期
基金：
日本学术振兴会;
关键词：
trachea; development; tubulogenesis; branching; physiology; FlyBook; EPITHELIAL TUBE-SIZE; FGF RECEPTOR HOMOLOG; BHLH-PAS PROTEIN; SEPTATE JUNCTION ORGANIZATION; COLLECTIVE CELL-MIGRATION; HOX-INDUCED ORGANOGENESIS; BRANCHING MORPHOGENESIS; EXTRACELLULAR-MATRIX; GENETIC-CONTROL; TRANSCRIPTION FACTOR;
D O I：
10.1534/genetics.117.300167
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the postembryonic stages, the same set of signaling pathways controls highly plastic regulation of size increase and pattern elaboration during larval stages, and cell proliferation and reprograming during metamorphosis. Tracheal tube morphogenesis is also regulated by physicochemical interaction of the cell and apical extracellular matrix to regulate optimal geometry suitable for air flow. The trachea system senses both the external oxygen level and the metabolic activity of internal organs, and helps organismal adaptation to changes in environmental oxygen level. Cellular and molecular mechanisms underlying the high plasticity of tracheal development and physiology uncovered through research on Drosophila are discussed.
引用
收藏
页码：367 / 380
页数：14
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