Wharton's Jelly Mesenchymal Stem Cell Administration Improves Quality of Life and Self-Sufficiency in Children with Cerebral Palsy: Results from a Retrospective Study

被引:18
作者
Boruczkowski, Dariusz [1 ]
Zdolinska-Malinowska, Izabela [1 ]
机构
[1] Polski Bank Komorek Macierzystych SA, FamiCord Grp, Polish Stem Cell Bank, Jana Pawla II 29, Warsaw, Poland
关键词
GROSS MOTOR FUNCTION; STROMAL CELLS; IN-VITRO; THERAPY; EFFICACY; FEASIBILITY; INFUSION;
D O I
10.1155/2019/7402151
中图分类号
Q813 [细胞工程];
学科分类号
摘要
The aim of this paper was to describe the outcome of the therapeutic administration of allogenic mesenchymal stem cells obtained from Wharton's jelly (WJ-MSCs) in children with cerebral palsy (CP) during a medical therapeutic experiment. We retrospectively analyzed the records of 109 patients recruited in daily clinical practice. Each patient received 1-10 injections and was examined by the same neurologist (study investigator (SI)) on the day of each infusion. The SI used a 6-point Likert scale to assess the quality of life (QoL) and self-sufficiency of the patients on the basis of the neurological examination. Children with >50% follow-ups after this administration were included into the quantitative analysis. In addition, the assessments of the parents and other health care professionals were obtained for 23 patients and compared with those of the SI. Forty-eight of 54 analyzed patients (88.9%) achieved some improvement in health status. Forty-eight (88.9%) patients experienced an increase in their QoL, and 21 patients (38.9%) achieved an increase in their self-sufficiency level. Improvement was achieved in 17 areas. Adverse events were mild and temporary except one case of epilepsy deterioration leading to treatment discontinuation. Age, body mass, and cell dose were not significant predictors of QoL response, contrary to epilepsy; developmental breakthrough was dose-dependent.
引用
收藏
页数:13
相关论文
共 42 条
[1]   Stem cell delivery of therapies for brain disorders [J].
Aleynik, Alexander ;
Gernavage, Kevin M. ;
Mourad, Yasmine S. H. ;
Sherman, Lauren S. ;
Liu, Katherine ;
Gubenko, Yuriy A. ;
Rameshwar, Pranela .
CLINICAL AND TRANSLATIONAL MEDICINE, 2014, 3
[2]   The efficacy of GMFM-88 and GMFM-66 to detect changes in gross motor function in children with cerebral palsy (CP): a literature review [J].
Alotaibi, Madawi ;
Long, Toby ;
Kennedy, Elizabeth ;
Bavishi, Siddhi .
DISABILITY AND REHABILITATION, 2014, 36 (08) :617-627
[3]  
[Anonymous], 2013, MATH PROBL ENG
[4]  
Bartley J, 2003, EXPERT OPIN BIOL TH, V3, P541, DOI 10.1517/eobt.3.4.541.21207
[5]   Cell therapy for neonatal hypoxia-ischemia and cerebral palsy [J].
Bennet, Laura ;
Tan, Sidhartha ;
Van den Heuij, Lotte ;
Derrick, Matthew ;
Groenendaal, Floris ;
van Bel, Frank ;
Juul, Sandra ;
Back, Stephen A. ;
Northington, Frances ;
Robertson, Nicola J. ;
Mallard, Carina ;
Gunn, Alistair Jan .
ANNALS OF NEUROLOGY, 2012, 71 (05) :589-600
[6]   Update on stem cell therapy for cerebral palsy [J].
Carroll, James E. ;
Mays, Robert W. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2011, 11 (04) :463-471
[7]   Neural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy [J].
Chen, Guojun ;
Wang, Yali ;
Xu, Zhenyu ;
Fang, Feng ;
Xu, Renmei ;
Wang, Yue ;
Hu, Xiaoli ;
Fan, Lixing ;
Liu, Houqi .
JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11
[8]   Intracranial Transplant of Olfactory Ensheathing Cells in Children and Adolescents With Cerebral Palsy: A Randomized Controlled Clinical Trial [J].
Chen, Lin ;
Huang, Hongyun ;
Xi, Haitao ;
Xie, Zihang ;
Liu, Ruiwen ;
Jiang, Zhao ;
Zhang, Feng ;
Liu, Yancheng ;
Chen, Di ;
Wang, Qingmiao ;
Wang, Hongmei ;
Ren, Yushui ;
Zhou, Changman .
CELL TRANSPLANTATION, 2010, 19 (02) :185-191
[9]  
Depczynska B., 2013, THESIS
[10]   Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement [J].
Dominici, M. ;
Le Blanc, K. ;
Mueller, I. ;
Slaper-Cortenbach, I. ;
Marini, F. C. ;
Krause, D. S. ;
Deans, R. J. ;
Keating, A. ;
Prockop, D. J. ;
Horwitz, E. M. .
CYTOTHERAPY, 2006, 8 (04) :315-317