Transition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO

被引：98

作者：

Baars, Hannah ^{[1
]}

Beyer, Astrid ^{[1
]}

Kohlhepp, Stefanie V. ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

关键词：

C-H ACTIVATION; CATALYZED SYNTHESIS; BUTOXIDE; SUBSTITUTION; CYCLIZATION; HYDROXIDE;

D O I：

10.1021/ol403414v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 degrees C. In this manner, diversely substituted products have been obtained in moderate to very good yields.

引用

页码：536 / 539

页数：4

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