LiBr-promoted photoredox neutral Minisci hydroxyalkylations of quinolines with aldehydes

被引：48

作者：

Ji, Xiaochen ^{[1
]}

Liu, Qiong ^{[1
]}

Wang, Zhongzhen ^{[1
]}

Wang, Pu ^{[1
]}

Deng, Guo-Jun ^{[1
]}

Huang, Huawen ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Key Lab Environm Friendly Chem & Appl, Xiangtan 411105, Peoples R China

来源：

GREEN CHEMISTRY | 2020年 / 22卷 / 23期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; BIOFILM FORMATION; HYDROGEN-ATOM; LIGHT; CATALYSIS; QUINOXALIN-2(1H)-ONES; METAL; PHOTOCATALYSIS; HETEROARENES; ALKYLATION;

D O I：

10.1039/d0gc01872d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoredox-neutral hydroxyalkylations of quinolines with aldehydes, induced by sustainable visible light under mild conditions, are described. Non-toxic and inexpensive LiBr is found to be the key for the success of the atom-economical Minisci method. Combined with a highly oxidative photocatalyst and visible light irradiation, the bromide additive mediates the H abstraction/acyl radical formation directly from aldehydes. The present mild photoredox neutral protocol provides an important alternative, especially for the challenging Minisci hydroalkylations, as well as a promising approach for atom-economical Minisci reactions with broader N-heterocycle spectra.

引用

页码：8233 / 8237

页数：5

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